Biomaterials I
Course Outline
Time
and Location
Lecture, to be determined
Instructor: R. S. Lakes, Professor
Text: Park, J.B. and Lakes, R. S., Biomaterials, Plenum, NY, second edition (1992) for earlier offerings of the course. A third edition is available as of 2007. Park, J.B. and Lakes, R. S., Biomaterials, Springer, third edition (2007).
References:
Van Vlack, Elements of Materials Science and Engineering
Weinstein, et al., ed,
Retrieval and Analysis of Orthopaedic Implants
Dumbleton and Black,
An Introduction to Orthopaedic Materials
Greener,
Harcourt, Lautenschlager,
Materials
Science in Dentistry
Description: Properties,
biocompatibility characteristics, and performance requirements
for
materials for implants.
Outline: 1 Anatomic
and physiological considerations
2 Physical
properties of natural and replacement materials
3 Response
of implants to the body environment
3.1 Chemical
breakdown
Corrosion
of metals
Degradation
of polymers
3.2 Mechanical
breakdown
fracture,
fatigue, wear, creep, synergistic effects
4 Response
of the body to implants
Cellular
basis for response
Infection
associated with implants
Toxicity
and carcinogenicity
Mechanical
effects on the body
5 Extracorporeal
applications of materials
6 Transplants
7 Regeneration
of tissues and organs
Lab
reports
: Reports
are due
two
weeks
after
the laboratory session is held. Report grades
will
be reduced by 10% for each working week of additional delay. Reports
should
be clear and understandable.
Experiments: Laboratory
experiments may include some of the following.
Experiment
Title
1 Determination of mechanical properties of bone and its replacements
2 Determination of viscoelastic properties of hard tissue
3 Determination of hard tissue properties
4 Determination of soft tissue properties: skin
5 Corrosion of metallic implants
6 Polymerization of cements and fillings: thermal and mechanical aspects
7 Characterization of shape memory alloy [Nitinol]
8 Interfacial behavior of biomaterials by holography
9 Foam
materials
10 Dental
materials
11 Evaluation of bone plate designs
12 Porous arterial graft
13 Toughness of PMMA cement: effect of porosity
A case study: Teflon based implants for the jaw to treat temporomandibular joint (TMJ) problems failed catastrophically. get pdf.